From WENN.com

The 40 Year Old Virgin star's actress wife Nancy plays his partner, who leaves his desperate character at the beginning of the movie.

Carell tells Parade.com, ""They used the take where her shoe came off in the car, and she bolted across that field with one shoe on. I don't think I've ever seen her run that fast.""

The actor admits it was the worst day to film the break-up: ""We shot the scene on our 17th anniversary. (The director) got us a cake and the crew sang Happy Anniversary to us.""